Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade …
Germanium sesquioxide (Scheme 1), IUPAC systematic name: 3-[(2-Carboxyethyl-oxogermyl)oxy-oxogermyl]propanoic acid, CAS-No. 1, also known under the synonyms propagermanium, proxigermanium, Ge-132, 2-carboxyethylgermasesquioxane, SK-818, or bis-(2-carboxyethylgermanium) sesquioxide, is the best known organogermanium drug.Its …
1. Introduction. Germanium is a naturally occurring, nonessential trace element found in soil, rocks, fresh water, plants (e.g., ginseng, aloe, and garlic), and in most foods, albeit in trace amounts [].Use of germanium-containing compounds as dietary supplements and medicines for promoting health became popular in the 1970s and 80s in Japan, Great Britain, …
Description. Product Name: AG Royal (Asai Germanium Royal) – Premium Organic Germanium Key Ingredient: Organic Germanium GE-132 (GE132) – Authentically sourced from Japan. Capsule Composition: Each capsule delivers 250mg of Asaigermanium GE-132 (GE132), enriched with the purity of Organic Germanium. Packaging Details: Total weight: 25.92g. …
Organic germanium is known to possess various biological and pharmacological activities, and is often used in medicine for purposes such as anti-tumor, antiviral, …
animals and humans, Ge-132 has been shown to support healthy immunity and immune survelliance. * Potentially, the body may use germanium as a cellular oxygenator. Organo-Germanium MINERALS ... (Organic Germanium). J Toxicology. 2020 Apr 4;2020:6275625. Menchikov LG, Ignatenko MA. Biological activity of organogermanium compounds
This is the same Germanium except in tablet form. Pure Ge-132 Organic Germanium is a unique organogermanium compound, bis-carboxyethyl germanium sesquioxide, sometimes called just germanium sesquioxide. It has unique molecular characteristics which make it non-toxic and permit it to be readily cleared in the urine as the intact molecule.*
Germanium has long been considered a therapeutic agent with anticancer, antitumor, antiaging, antiviral and anti-inflammatory effects. Numerous clinical studies have …
In fact, the toxicity of organic germanium compounds [55,56,57,58,59,60] is lower than that of table salt and inorganic germanium dioxide, for which the oral toxicity for mice (LD 50) is 5400 mg/kg . For example, for the best-known organic germanium sesquioxide Ge-132 oral toxicity for mice is LD 50 > 6300 mg/kg, oral for rats is >10,000 mg/kg ...
(50), is an organic germanium compound being chronic toxicity, after 24 weeks, O-50 mg/kg/day, THERAPEUTIC EFFECTS OF ORGANIC GERMANIUM 209 no symptoms of disease were detected.
Organic germanium is the most widely used form of germanium. Compared to the common metal (mercury, cadmium, lead, etc.), organic germanium is much less toxic to humans than others. Since its discovery in 1886, organic germanium and relative compounds have caused many medically related problems across the globe. In most cases, organic germanium ...
With the development of organic germanium and nanotechnology, germanium serves multiple biological functions, and its potential value in biochemistry and medicine has increasingly captured the attention of researchers. In recent years, germanium has gradually gained significance as a material in the …
Both inorganic and organic germanium products, which have different biological activities, have been promoted to treat a wide range of diseases including cancer and AIDS. Germanium compounds have immunomodulating and antioxidant activities . Spirogermanium, an azaspiran compound, was investigated as an anticancer drug.
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Pure Ge-132 Organic Germanium is a unique organogermanium compound, bis-carboxyethyl... $79.29 + Add to Cart The item has been added. Add Wish List Quick view ... Balanced levels of serotonin are thought to support the body's ability to maintain balance in... $62.39 + Add to Cart The item has been added.
Organic germanium is believed to have anticancer, antitumor, antiaging, antiviral, antimicrobial, anti-inflammatory, immunity enhancing and antioxidant effects. ... There are inadequate scientific studies to support the use of germanium. Germanium can cause many adverse effects and damage organ systems. Avoid use. Germanium may exacerbate seizures.
L. G. Menchikov & M. A. Ignatenko. 763 Accesses. 41 Citations. Explore all metrics. Data on the main biologically active organogermanium compounds that were …
Germanium's anti-viral and immunological properties, including the induction of interferon, macrophages, T-suppressor cells and augmentation of natural killer cell activity, …
INTRODUCTION. Poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) is the most common organic germanium compound.It was first synthesized by Oikawa et al., and the structure has been previously reported [].Ge-132 is water soluble, and its safety has been confirmed [].The structures of Ge-132 and trihydroxy germyl propanoic acid, a product of the …
Poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) is the most common organic germanium compound. The ingestion of Ge-132 promotes bile secretion.
Pure Ge-132 Organic Germanium is a unique organogermanium compound, bis-carboxyethyl germanium sesquioxide, sometimes called just germanium sesquioxide. It has unique molecular characteristics which make it virtually unreactive in the body, and its small particle size and unique structure permit it to be readily cleared in the urine as the ...
Recent Advances in Acidity, Complexing, Basicity and H-Bonding of Organo Germanium, Tin and Lead Compounds (Pages: 461-536) Claudia M. Rienäcker, Thomas M. Klapötke, Summary
Ge-132 is a synthetic organic germanium that is used as a dietary supplement. The antioxidant activity of Ge-132 on cultured mammalian cells was investigated in this study. First, Ge-132 cytotoxicity on mammalian cultured cells was determined by measuring lactate dehydrogenase (LDH) levels. Ge-132 h …
Germanium sesquioxide (Ge-132), an organic compound that is supposed to have lower toxicity, has been marketed as a dietary supplement to help fight cancer. In a …
The common water-soluble organic germanium compound poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) exhibits activities related to immune responses and antioxidant induction. In this study, we evaluated the antioxidative effect of dietary Ge-132 in the plasma of mice. Male ICR mice (seven mice per group) received an AIN-76 diet with 0. ...
Its therapeutic attributes include immuno-enhancement, oxygen enrichment, free radical scavenging, analgesia and heavy metal detoxification. Toxicological studies document …
Chapter 1 – The history of organic germanium. Chapter 2 – The three main types of organic germanium. Chapter 3 – How organic germanium builds the cancer-critical parts of the immunity system. Chapter 4 – Organic germanium helps enrich the body with oxygen and is a superb anti-oxidant. Chapter 5 – Chelates heavy metals from body (which ...
Germanium is a rare earth mineral with many health benefits. This rare earth mineral is commonly overlooked, but Germanium has some powerful qualities for good health.. Germanium increases the circulation of blood to your brain, supports your immune system, and is an antioxidant that removes heavy metals.. Germanium helps with osteoarthritis, rheumatoid …
Both the elemental germanium and germanium dioxide (GeO 2) are the inorganic Ge, while the organic Ge compounds include β-carboxyethyl germanium (Ge-132), spiro-germanium, proxi-germanium and so on (Han et al., 2007; Cheong et al., 2009). Organic germanium compounds, especially for Ge-132, has been widely used as medical applications …
Germanium shares the group 14 with silicon, tin and lead in the periodic table. One reason for the limited synthetic value of organic synthetic germanium compounds is the cost of germanium compounds. However, germanium is considered as a non-toxic alternative of many toxic organotin reagents.
Facile synthesis of germanium nanocrystals and their application in organic-inorganic hybrid photodetectors Adv Mater . 2011 Aug 23;23(32):3704-7. doi: 10.1002/adma.201101436.
But there is no good scientific evidence to support these or other uses. ... A typical daily diet includes 0.4-3.4 mg of germanium. Organic forms of germanium are POSSIBLY UNSAFE when taken by ...
Pure Ge-132 Organic Germanium is a unique organogermanium compound, bis-carboxyethyl germanium sesquioxide, sometimes called just germanium sesquioxide. It has unique molecular characteristics which make it virtually unreactive in the body, and its small particle size and unique structure permit it to be readily cleared in the urine as the ...
Poly-trans-[(2-carboxyethyl)germasesquioxane], Ge-132, is a water-soluble organic germanium compound with many reported physiological functions.The hydrolysate of Ge-132, 3-(trihydroxygermyl)propanoic acid, can interact with diol compounds; therefore, it can possibly interact with diol-containing sugar compounds, which have important physiological …
